There are
1,285 mi
from Port St Lucie, FL to Keokuk, IA
That's the driving distance. It would take 23 hours 50 mins to go from Port St Lucie, Florida to Keokuk, Iowa.
The flight distance (direct flight from Port St Lucie, FL to Keokuk, IA) is 1,104.28 mi.
1,285 mi = 1.61 kms