There are
1,206 mi
from Port St Lucie, FL to Griffith, IN
That's the driving distance. It would take 22 hours 36 mins to go from Port St Lucie, Florida to Griffith, Indiana.
The flight distance (direct flight from Port St Lucie, FL to Griffith, IN) is 1,063.04 mi.
1,206 mi = 1.61 kms