Miles between Port St Lucie, FL and Greenwood, SC

There are
545 mi
from Port St Lucie, FL to Greenwood, SC

That's the driving distance. It would take 10 hours 35 mins to go from Port St Lucie, Florida to Greenwood, South Carolina.

The flight distance (direct flight from Port St Lucie, FL to Greenwood, SC) is 489.96 mi.

545 mi = 877.67 kms