Miles between Port St Lucie, FL and Greenville, SC

There are
622 mi
from Port St Lucie, FL to Greenville, SC

That's the driving distance. It would take 11 hours 20 mins to go from Port St Lucie, Florida to Greenville, South Carolina.

The flight distance (direct flight from Port St Lucie, FL to Greenville, SC) is 537.19 mi.

622 mi = 1,001.17 kms