Miles between Port St Lucie, FL and Florence, SC

There are
542 mi
from Port St Lucie, FL to Florence, SC

That's the driving distance. It would take 9 hours 55 mins to go from Port St Lucie, Florida to Florence, South Carolina.

The flight distance (direct flight from Port St Lucie, FL to Florence, SC) is 479.39 mi.

542 mi = 872.99 kms