Miles between Port St Lucie, FL and Cape Girardeau, MO

There are
1,005 mi
from Port St Lucie, FL to Cape Girardeau, MO

That's the driving distance. It would take 18 hours 41 mins to go from Port St Lucie, Florida to Cape Girardeau, Missouri.

The flight distance (direct flight from Port St Lucie, FL to Cape Girardeau, MO) is 874.60 mi.

1,005 mi = 1.61 kms