Miles between Port St Lucie, FL and Bluffton, SC

There are
400 mi
from Port St Lucie, FL to Bluffton, SC

That's the driving distance. It would take 7 hours 20 mins to go from Port St Lucie, Florida to Bluffton, South Carolina.

The flight distance (direct flight from Port St Lucie, FL to Bluffton, SC) is 344.13 mi.

400 mi = 643.86 kms