There are
380 mi
from Poplar Bluff, MO to Seymour, IN
That's the driving distance. It would take 7 hours 10 mins to go from Poplar Bluff, Missouri to Seymour, Indiana.
The flight distance (direct flight from Poplar Bluff, MO to Seymour, IN) is 288.88 mi.
380 mi = 611.57 kms