There are
464 mi
from Poplar Bluff, MO to Prospect Heights, IL
That's the driving distance. It would take 8 hours 37 mins to go from Poplar Bluff, Missouri to Prospect Heights, Illinois.
The flight distance (direct flight from Poplar Bluff, MO to Prospect Heights, IL) is 391.38 mi.
464 mi = 747.33 kms