There are
506 mi
from Poplar Bluff, MO to Mishawaka, IN
That's the driving distance. It would take 9 hours 29 mins to go from Poplar Bluff, Missouri to Mishawaka, Indiana.
The flight distance (direct flight from Poplar Bluff, MO to Mishawaka, IN) is 407.60 mi.
506 mi = 814.47 kms