There are
422 mi
from Poplar Bluff, MO to Midlothian, IL
That's the driving distance. It would take 7 hours 42 mins to go from Poplar Bluff, Missouri to Midlothian, Illinois.
The flight distance (direct flight from Poplar Bluff, MO to Midlothian, IL) is 365.55 mi.
422 mi = 679.61 kms