There are
451 mi
from Poplar Bluff, MO to Lake In The Hills, IL
That's the driving distance. It would take 8 hours 52 mins to go from Poplar Bluff, Missouri to Lake In The Hills, Illinois.
The flight distance (direct flight from Poplar Bluff, MO to Lake In The Hills, IL) is 390.59 mi.
451 mi = 725.35 kms