There are
884 mi
from Poplar Bluff, MO to Hyattsville, MD
That's the driving distance. It would take 16 hours 46 mins to go from Poplar Bluff, Missouri to Hyattsville, Maryland.
The flight distance (direct flight from Poplar Bluff, MO to Hyattsville, MD) is 748.41 mi.
884 mi = 1,423.38 kms