There are
437 mi
from Poplar Bluff, MO to Griffith, IN
That's the driving distance. It would take 8 hours 4 mins to go from Poplar Bluff, Missouri to Griffith, Indiana.
The flight distance (direct flight from Poplar Bluff, MO to Griffith, IN) is 366 mi.
437 mi = 702.64 kms