There are
356 mi
from Poplar Bluff, MO to Crossville, TN
That's the driving distance. It would take 6 hours 40 mins to go from Poplar Bluff, Missouri to Crossville, Tennessee.
The flight distance (direct flight from Poplar Bluff, MO to Crossville, TN) is 303.73 mi.
356 mi = 572.68 kms