There are
405 mi
from Poplar Bluff, MO to Brookhaven, MS
That's the driving distance. It would take 7 hours 50 mins to go from Poplar Bluff, Missouri to Brookhaven, Mississippi.
The flight distance (direct flight from Poplar Bluff, MO to Brookhaven, MS) is 357.77 mi.
405 mi = 652.44 kms