There are
2,044 mi
from Pleasanton, CA to St Charles, MO
That's the driving distance. It would take 1 day 11 hours to go from Pleasanton, California to St Charles, Missouri.
The flight distance (direct flight from Pleasanton, CA to St Charles, MO) is 1,695.77 mi.
2,044 mi = 3,289.62 kms