There are
1,769 mi
from Palo Alto, CA to Sioux Falls, SD
That's the driving distance. It would take 1 day 6 hours to go from Palo Alto, California to Sioux Falls, South Dakota.
The flight distance (direct flight from Palo Alto, CA to Sioux Falls, SD) is 1,395.45 mi.
1,769 mi = 2,846.49 kms