There are
1,812 mi
from Palmdale, CA to Sikeston, MO
That's the driving distance. It would take 1 day 7 hours to go from Palmdale, California to Sikeston, Missouri.
The flight distance (direct flight from Palmdale, CA to Sikeston, MO) is 1,602.02 mi.
1,812 mi = 2,916.80 kms