There are
1,797 mi
from Palmdale, CA to Lake St Louis, MO
That's the driving distance. It would take 1 day 7 hours to go from Palmdale, California to Lake St Louis, Missouri.
The flight distance (direct flight from Palmdale, CA to Lake St Louis, MO) is 1,535.85 mi.
1,797 mi = 1.61 kms