There are
2,292 mi
from Palmdale, CA to Greenville, SC
That's the driving distance. It would take 1 day 16 hours to go from Palmdale, California to Greenville, South Carolina.
The flight distance (direct flight from Palmdale, CA to Greenville, SC) is 2,017.94 mi.
2,292 mi = 3.22 kms