There are
1,821 mi
from Palmdale, CA to Edwardsville, IL
That's the driving distance. It would take 1 day 8 hours to go from Palmdale, California to Edwardsville, Illinois.
The flight distance (direct flight from Palmdale, CA to Edwardsville, IL) is 1,580.87 mi.
1,821 mi = 1.61 kms