There are
2,507 mi
from Palmdale, CA to Depew, NY
That's the driving distance. It would take 1 day 20 hours to go from Palmdale, California to Depew, New York.
The flight distance (direct flight from Palmdale, CA to Depew, NY) is 2,179.45 mi.
2,507 mi = 3.22 kms