There are
1,851 mi
from Palmdale, CA to Cape Girardeau, MO
That's the driving distance. It would take 1 day 8 hours to go from Palmdale, California to Cape Girardeau, Missouri.
The flight distance (direct flight from Palmdale, CA to Cape Girardeau, MO) is 1,604.61 mi.
1,851 mi = 1.61 kms