There are
1,752 mi
from Palm Desert, CA to Sikeston, MO
That's the driving distance. It would take 1 day 6 hours to go from Palm Desert, California to Sikeston, Missouri.
The flight distance (direct flight from Palm Desert, CA to Sikeston, MO) is 1,521.03 mi.
1,752 mi = 2,820.34 kms