There are
393 mi
from Palatine, IL to Cape Girardeau, MO
That's the driving distance. It would take 7 hours 28 mins to go from Palatine, Illinois to Cape Girardeau, Missouri.
The flight distance (direct flight from Palatine, IL to Cape Girardeau, MO) is 341.18 mi.
393 mi = 632.60 kms