There are
322 mi
from Owensboro, KY to Hannibal, MO
That's the driving distance. It would take 6 hours 14 mins to go from Owensboro, Kentucky to Hannibal, Missouri.
The flight distance (direct flight from Owensboro, KY to Hannibal, MO) is 265.09 mi.
322 mi = 517.93 kms