There are
272 mi
from Overland Park, KS to Edwardsville, IL
That's the driving distance. It would take 5 hours 21 mins to go from Overland Park, Kansas to Edwardsville, Illinois.
The flight distance (direct flight from Overland Park, KS to Edwardsville, IL) is 253.93 mi.
272 mi = 437.02 kms