There are
1,006 mi
from Overland Park, KS to Cayce, SC
That's the driving distance. It would take 18 hours 58 mins to go from Overland Park, Kansas to Cayce, South Carolina.
The flight distance (direct flight from Overland Park, KS to Cayce, SC) is 830 mi.
1,006 mi = 1.61 kms