There are
263 mi
from Overland Park, KS to Cahokia, IL
That's the driving distance. It would take 5 hours 10 mins to go from Overland Park, Kansas to Cahokia, Illinois.
The flight distance (direct flight from Overland Park, KS to Cahokia, IL) is 242.99 mi.
263 mi = 424.00 kms