There are
543 mi
from Oshkosh, WI to Cape Girardeau, MO
That's the driving distance. It would take 10 hours 16 mins to go from Oshkosh, Wisconsin to Cape Girardeau, Missouri.
The flight distance (direct flight from Oshkosh, WI to Cape Girardeau, MO) is 467.02 mi.
543 mi = 874.06 kms