There are
781 mi
from Orland Park, IL to Brookhaven, MS
That's the driving distance. It would take 14 hours 9 mins to go from Orland Park, Illinois to Brookhaven, Mississippi.
The flight distance (direct flight from Orland Park, IL to Brookhaven, MS) is 709.04 mi.
781 mi = 1,256.96 kms