There are
537 mi
from Omaha, NE to Cape Girardeau, MO
That's the driving distance. It would take 10 hours 4 mins to go from Omaha, Nebraska to Cape Girardeau, Missouri.
The flight distance (direct flight from Omaha, NE to Cape Girardeau, MO) is 440.75 mi.
537 mi = 864.86 kms