There are
281 mi
from Olathe, KS to Edwardsville, IL
That's the driving distance. It would take 5 hours 29 mins to go from Olathe, Kansas to Edwardsville, Illinois.
The flight distance (direct flight from Olathe, KS to Edwardsville, IL) is 261.86 mi.
281 mi = 451.95 kms