There are
1,460 mi
from North Charleston, SC to Sioux Falls, SD
That's the driving distance. It would take 1 day 2 hours to go from North Charleston, South Carolina to Sioux Falls, South Dakota.
The flight distance (direct flight from North Charleston, SC to Sioux Falls, SD) is 1,166.91 mi.
1,460 mi = 2,350.42 kms