There are
2,487 mi
from North Charleston, SC to Simi Valley, CA
That's the driving distance. It would take 1 day 20 hours to go from North Charleston, South Carolina to Simi Valley, California.
The flight distance (direct flight from North Charleston, SC to Simi Valley, CA) is 2,222.82 mi.
2,487 mi = 4,001.69 kms