There are
829 mi
from North Charleston, SC to Poughkeepsie, NY
That's the driving distance. It would take 16 hours 2 mins to go from North Charleston, South Carolina to Poughkeepsie, New York.
The flight distance (direct flight from North Charleston, SC to Poughkeepsie, NY) is 695.47 mi.
829 mi = 1,333.76 kms