There are
1,458 mi
from North Charleston, SC to Lexington, NE
That's the driving distance. It would take 1 day 3 hours to go from North Charleston, South Carolina to Lexington, Nebraska.
The flight distance (direct flight from North Charleston, SC to Lexington, NE) is 1,218.80 mi.
1,458 mi = 2,346.88 kms