There are
2,917 mi
from North Charleston, SC to Issaquah, WA
That's the driving distance. It would take 2 days 3 hours to go from North Charleston, South Carolina to Issaquah, Washington.
The flight distance (direct flight from North Charleston, SC to Issaquah, WA) is 2,403.39 mi.
2,917 mi = 4,694.73 kms