There are
1,218 mi
from Newton, MA to Cape Girardeau, MO
That's the driving distance. It would take 23 hours 16 mins to go from Newton, Massachusetts to Cape Girardeau, Missouri.
The flight distance (direct flight from Newton, MA to Cape Girardeau, MO) is 1,029.40 mi.
1,218 mi = 1.61 kms