There are
886 mi
from Newport News, VA to Cape Girardeau, MO
That's the driving distance. It would take 16 hours 32 mins to go from Newport News, Virginia to Cape Girardeau, Missouri.
The flight distance (direct flight from Newport News, VA to Cape Girardeau, MO) is 717.56 mi.
886 mi = 1,425.39 kms