There are
2,457 mi
from National City, CA to Roanoke, VA
That's the driving distance. It would take 1 day 18 hours to go from National City, California to Roanoke, Virginia.
The flight distance (direct flight from National City, CA to Roanoke, VA) is 2,113.81 mi.
2,457 mi = 3,954.31 kms