There are
1,876 mi
from Murrieta, CA to Cape Girardeau, MO
That's the driving distance. It would take 1 day 9 hours to go from Murrieta, California to Cape Girardeau, Missouri.
The flight distance (direct flight from Murrieta, CA to Cape Girardeau, MO) is 1,574.85 mi.
1,876 mi = 1.61 kms