There are
390 mi
from Mt Prospect, IL to Cape Girardeau, MO
That's the driving distance. It would take 7 hours 23 mins to go from Mt Prospect, Illinois to Cape Girardeau, Missouri.
The flight distance (direct flight from Mt Prospect, IL to Cape Girardeau, MO) is 339.47 mi.
390 mi = 628.42 kms