Miles between Mt Pleasant, SC and Knoxville, TN

There are
376 mi
from Mt Pleasant, SC to Knoxville, TN

That's the driving distance. It would take 7 hours 12 mins to go from Mt Pleasant, South Carolina to Knoxville, Tennessee.

The flight distance (direct flight from Mt Pleasant, SC to Knoxville, TN) is 318.40 mi.

376 mi = 605.82 kms