Miles between Mt Pleasant, SC and Key West, FL

There are
747 mi
from Mt Pleasant, SC to Key West, FL

That's the driving distance. It would take 15 hours 2 mins to go from Mt Pleasant, South Carolina to Key West, Florida.

The flight distance (direct flight from Mt Pleasant, SC to Key West, FL) is 580.96 mi.

747 mi = 1,202.05 kms