There are
460 mi
from Missoula, MT to Issaquah, WA
That's the driving distance. It would take 8 hours 20 mins to go from Missoula, Montana to Issaquah, Washington.
The flight distance (direct flight from Missoula, MT to Issaquah, WA) is 378.86 mi.
460 mi = 740.38 kms