There are
1,715 mi
from Missoula, MT to Cape Girardeau, MO
That's the driving distance. It would take 1 day 5 hours to go from Missoula, Montana to Cape Girardeau, Missouri.
The flight distance (direct flight from Missoula, MT to Cape Girardeau, MO) is 1,411 mi.
1,715 mi = 1.61 kms