There are
2,681 mi
from Mission Viejo, CA to Hyattsville, MD
That's the driving distance. It would take 1 day 23 hours to go from Mission Viejo, California to Hyattsville, Maryland.
The flight distance (direct flight from Mission Viejo, CA to Hyattsville, MD) is 2,279.28 mi.
2,681 mi = 4,314.24 kms