There are
1,087 mi
from Milford, CT to Cape Girardeau, MO
That's the driving distance. It would take 20 hours 50 mins to go from Milford, Connecticut to Cape Girardeau, Missouri.
The flight distance (direct flight from Milford, CT to Cape Girardeau, MO) is 919.35 mi.
1,087 mi = 1,750.04 kms